If you’re a person who has been diagnosed with schizophrenia, should you take drugs that are known to reduce brain volume? 2013: Another study analyzed the influences of antipsychotic treatment and “relapse” on brain volume among those with schizophrenia. Do you think it’s worth risking brain volume to help you fall asleep? (Editorial).British Journal of Psychiatry, 198, 85-87. Now, many doctors serve as mere puppets for the pharmaceutical heavyweights, unknowingly prescribing antipsychotics that cause long-term brain damage. Dear Kate, I have been diagnosed with Schizophrenia and I had to take many drugs many times prescribed by many specialists. This lead to the idea that psychosis is a toxic brain state, and was used to justify the claim that early treatment with antipsychotics was necessary to prevent brain damage. They highlighted the fact that one study showed varying degrees of volume loss with a variety of antipsychotics, whereas another study determined that volume changes were associated with taking any antipsychotic compared to lack of treatment (e.g. Assuming you wanted to track brain volume changes to yourself over time, you could get a baseline “pre-treatment” brain scan followed by another every 6 months, every year, or even every couple years. For three and a half years I’ve been on atypical antipsychotics. How is an IQ test greater than 95% accurate anyway when everything changes in years going by? Learning to deviate your delusions towards truth may not be possible if you are not a very logical person, so in that event your IQ may very well go down because you have spent years believing horrible stuff without actually denying it yourself. Brain injuries occur due to a wide range of internal and external factors. It’s certainly difficult to knowingly expose yourself to a substance that decreases cortical volume. 1) presence of hallucinations or delusions. It’s pretty important information for making decisions of care and it all seems to be in conflict depending upon which study you read. Do not trust psychiatrists, they have no idea what they are doing. They are really bad for your health, so only take them when absolutely necessary, and for the less possible amount of time. Maybe reduced volume doesn’t necessarily mean reduced intelligence, but it doesn’t take a stretch to imagine it. The upside is that brain volume reductions as a result of treatment aren’t generally regarded as severe. However, there is beauty in any brain damage. Researchers discovered that the duration of treatment and dosage of the antipsychotic was associated with reductions in brain volume and increased cerebrospinal fluid volume. I have done approximately 10 IQ tests in 20 yrs and I have had a deviation of 26 points overall. Exploring Benefits of Human-Horse Relationships, Pantoprazole (Protonix) vs. Omeprazole (Prilosec), Lexapro (Escitalopram) vs. Prozac (Fluoxetine), Pregabalin (Lyrica) vs. Gabapentin (Neurontin). And, regardless of the cause-and-effect realities involved, immediate clinical attention for symptoms of psychosis is widely recommended. hearing voices) and various types of delusions (e.g. A general shrinkage in the brains of those treated with antipsychotics was an estimated 20%. The loss was most pronounced in the prefrontal and parietal lobes. Every person is different, and one person with less severe schizophrenia may respond well to medication prescribed at a lower dose than another individual. I’m a total crazy person, but I like being this way. The researchers used a randomized, controlled trial (RCT) design, which allows them to suggest that the drugs cause the observed effect on the brain. (Neurotoxicity), L-Theanine Benefits (Scientific Research), Drug-Induced Psychosis: List Of Causative Agents, Genetic Clusters Suggest Schizophrenia Is 8 Distinct Diseases, HOCD (Homosexual Obsessive Compulsive Disorder): Causes, Symptoms, Treatment, What is Equine Therapy? Researchers are starting to recognize the importance of taking a “minimal effective dose” rather than titrating up to a specific therapeutic threshold dosage. In fact, then they started to harass me, disguised email address etc. Antipsychotics are medications that should only be taken by individuals with conditions warranting them. Lexapro (Escitalopram) vs Zoloft (Sertraline): Extensive Comparison. Been on antipsychotics for seven months and suspected they were affecting me negatively, but I lacked evidence until I stumbled across this article. There are many neuroprotective agents and nootropics, some of which may combat volume loss stemming from your medication. Also keep in mind that certain atypical antipsychotics may be safer and more targeted than others, allowing you to take a lower dose. 2009: In a report published in 2009, researchers attempted to determine whether antipsychotic medications may change regional brain volumes in humans. An untreated episode of psychosis can result in structural brain damage due to neurotoxicity. 3) psychosis is not better accounted for by another mental disorder. The authors of the study suggest conducting careful risk-benefit analyses when prescribing these drugs; especially for “off-label” conditions. It was noted that there were differences between atypical antipsychotics (newer) and typical antipsychotics (older) in regards to their effect on the basal ganglia. Exploring Benefits of Human-Horse Relationships. You can also subscribe without commenting. Fortunately, preliminary evidence suggests that volumetric decreases are more severe among rodents and non-human primates than in human populations. They took her off of all her medications, didn’t use the advice of an M.D. Psychiatry is a joke. Even after controlling for illness duration, severity, and substance abuse – antipsychotics appeared to decrease brain tissue volume. At baseline it was noted that those with schizophrenia had significant reductions in brain volume and increases in volume of the lateral ventricle (LV) region compared to controls. Others believe that inflammation in the brain may damage cells that are used for thinking and perception. But when you feel better again, stop taking them, but not suddenly. Antipsychotics are also commonly utilized as antidepressant augmentation strategies. Many people call me insane (Yes, my way of life has zero sense to them), what I tell them is totally nonsense. Dopamine Researchers believe dopamine plays an important role in psychosis. They conducted a systematic review of all studies incorporating structural MRI scans among those using antipsychotics. Schizophrenia causes brain damage…ap’s stop the brain damage. Despite the fact that psychotic symptoms are controlled by antipsychotics, those undergoing treatment often experience an array of damning side effects, including: severe weight gain, sexual dysfunction, hormonal imbalances, and in some cases diabetes. Researchers hypothesize different effects on the thalamus. Do they also engineer brain cell death and deterioration? Many users of antipsychotics experience cognitive deficits that are thought to be solely from their illness, when in reality they may be a result of the meds. Yes. Since you know you’ll be taking an antipsychotic, you may want to take extra steps to potentially mitigate volumetric loss associated with treatment. They are both kind of important for deciding how much Ap’s to take. I think a lot of that varies from individual to individual. Psychosis is the most extreme symptom of methamphetamine addiction and a clear indication that the brain damage suffered has been significant. Learn how your comment data is processed. In other words, you should have experienced schizophrenia and/or a psychotic break. It is shrunk. While some research suggests that the illness itself (schizophrenia) and symptomatic relapse may contribute to volumetric brain shrinkage, most evidence points to antipsychotics as the primary causative factor; particularly the duration of treatment and dosage. I have been on antipsychotics for over a decade now. Probably caused by 20 plus years of injections-antipsychotics and oral form, antidepressants, mood stabilisers, deep sleep therapy, Valium and other sedatives, sleep medication, ECT and harmful comments from psychiatric staff. Yes, my brain is totally damaged according to you, and I even feel the decayed brain with insufficient cerebra spinal fluid flow. Typical antipsychotics increased basal ganglia volume, whereas atypical antipsychotics did not. The benefits associated with taking antipsychotics for those with schizophrenia are thought to considerably outweigh drawbacks – including volumetric reductions. At least for 1/3 of people with schizophrenia, psychosis does not cause brain damage: In a study of more than 300 patients from three continents, over one third had brains that looked similar to healthy people. It shrinks our brains and damages them. This study suggested that humans may endure similar volume reductions as these monkeys. Approved uses for antipsychotics include treating individuals diagnosed with schizophrenia, bipolar disorder, and cases of drug-induced psychosis. To sum up, if the symptoms reduce the quality of life in the extreme, then take them. Evidence from this study indicated that antipsychotics induced regional changes in the brain rather than widespread, global alterations. And the damage is what happens if it is left to not fix itself either via itself or via medication. Thank you for this article. I think mostly superficial people want to control people. For the study, researchers evaluated the influence of 4 factors on brain volume including: duration of illness, antipsychotic treatment, severity of illness, and substance abuse. There are also many supplements that you could consider to help offset antipsychotic-induced brain damage. Notify me of followup comments via e-mail. It took awhile before researchers considered the fact that maybe the brain volume loss among those with schizophrenia may actually be a result of their antipsychotic treatment. Are you even kidding about it being worth taking antipsychotics? This means that a person’s brain with schizophrenia who has undergone years of antipsychotic treatment (especially at high doses), may display signs of neurodegeneration. Still, medical professionals should work with patients to come up with harm reduction strategies. For the review, researchers were able to incorporate 30 longitudinal studies. Results indicated that individuals being treated with Haldol had significantly less grey matter than those being treated with Zyprexa. lithium) that can be utilized over a long-term without any significant brain volume loss. It KILLS YOU. They noted that the longer an individual had been treated and the higher the dose of the medication, the greater the volume loss associated with the medication. Unfortunately many people are taking antipsychotics as treatments for conditions that do not warrant their usage. At 54 and no money to access urgent further assessments or useful help and fear of being referred back to psychiatry stressful and soul destroying, but MRI showing global shrinkage of brain with lack of specialists or help in rural Wales U.K. extra daunting and a worry for my young husband. (Editorial).British Journal of Psychiatry, 198, 85-87. We're Here to Help. The number of relapses a person had didn’t affect brain volume. © MentalHealthDaily.com 2013-2019 | Privacy Policy | Legal Notice | Affiliate Disclosure, How to Improve Psychiatric Treatment Outcomes, Air Pollution Causes Brain Damage (Scientific Research), Does Fluoride In Drinking Water Cause Brain Damage? Everyone is vulnerable to a psychotic disorder and psychosis will result when a threshold of damage to these areas are attained. Global brain shrinkage at moderate level. what if the damage of the brain is from the Aps withdrawal itself (when a person starts a Aps before) as there are no mri scan of the brian of a untreated schizophrenic , right ?Who knows ? The only people that should be taking antipsychotics are individuals diagnosed with conditions that provoke psychotic symptoms. I guess you go with what I’ve thought for awhile: Take the minimum dose that keeps you from having Psychosis and keeps the side effects from the Ap’s to a minimum. Since those taking antipsychotics experience reductions in white matter, the communication system within their brain becomes impaired. Global brain volume loss: Studies have noted that antipsychotics reduce global brain volume. 4) psychosis does not occur exclusively during a state of delirium. However, we are left with the additional dilemma that a longer duration of untreated psychosis (DUP) may also be neurotoxic. Oddly enough, they didn’t suggest that brain volume decreased from antipsychotic usage. That’s a MILLION times worse that what conventional psychiatry does to people. Luckily they all went up gradually. The symptoms are sz. New evidence based on neuroimaging studies confirmed the fact that antipsychotic drugs were actually causing brain damage in the form of volume loss and shrinkage. All they ever do is show schizophrenics as criminals, when most are probably more sensitive than other people. From a structural standpoint, the answer depends upon what is causing the psychosis. It may be nonsense to you too, but if you find it interesting to have a damaged brain which loves to heal itself by healing mother earth. However, they couldn’t ignore the fact that animal studies involving administration of antipsychotics demonstrated decreases in brain tissue volume. 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